Registration Dossier
Registration Dossier
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EC number: 200-824-2 | CAS number: 74-95-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Guidance on registration Reference: ECHA-16-G-06-EN Publ.date:November 2016
Practical guide 2: How to report weight of evidence - Reference: ECHA-10-B-05-EN Publ.date: 24/03/2010
"Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals" (ECHA 2008)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxtree - Toxic Hazard Estimation by decision tree approach
- Author:
- Ideaconsult Ltd
- Year:
- 2 016
- Bibliographic source:
- http://toxtree.sourceforge.net/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
Test material
- Reference substance name:
- Dibromomethane
- EC Number:
- 200-824-2
- EC Name:
- Dibromomethane
- Cas Number:
- 74-95-3
- Molecular formula:
- CH2Br2
- IUPAC Name:
- dibromomethane
1
- Specific details on test material used for the study:
- smile: C(Br)Br
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: qualitative estimation
- Remarks on result:
- no indication of irritation
In vivo
Results
- Irritation parameter:
- other: qualitative estimation
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Q1.Melting
Point[℃]
> 200 No
C(Br)Br
Q2.LogP-3.1 No
C(Br)Br
Q3.Lipid
Solubility[g/kg] 0,01 No
C(Br)Br
Q4.Group
C (C,H,O) No
C(Br)Br
Q9.Group
CN (C,H,O,N) No
C(Br)Br
Q19.Group
CNHal (C,H,O,N,F,Cl,Br or I ) No
C(Br)Br
Q27.Group
CNS (C,H,O,N,S) No
C(Br)Br
Q33.Group
CHal (C,H,O,F,Cl,Br or I ) No
C(Br)Br
Q36.AlphaAlkynes No
C(Br)Br
Q4.Group
C (C,H,O) No
C(Br)Br
Q9.Group
CN (C,H,O,N) No
C(Br)Br
Q19.Group
CNHal (C,H,O,N,F,Cl,Br or I ) No
C(Br)Br
Q27.Group
CNS (C,H,O,N,S) No
C(Br)Br
Q33.Group
CHal (C,H,O,F,Cl,Br or I ) No Class UnknownC(Br)Br
Result: Not irritant
Applicant's summary and conclusion
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