Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 696-231-5 | CAS number: 1361000-03-4
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The Partition Coefficient (n-octanol/water), log Pow, of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate at ambient temperature was 3.045 and 1.287 at pH 3 and 7 respectively (measured by the HPLC method OECD 117).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.287
- at the temperature of:
- 20 °C
Additional information
The Partition Coefficient of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate was determined according to the OECD 117 guideline (Partition Coefficient (n-octanol/water) using High Performance Liquid Chromatography (HPLC) and following GLP.
The test was conducted with a test material concentration of 4 mg/L in mobile phase consisting of methanol and HPLC water (65:35 v/v) (with potassium phosphate salts). The experiment was performed at two different pH conditions (pH 3 and 7) and at ambient temperature. Samples of the test material were analyzed via HPLC.
Calibration was performed using eight reference materials. Dead time of the HPLC-system was determined three fold using 0.1 mL of thiourea in mobile phase.
The Partition Coefficient (n-octanol/water), log Pow, of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate was 3.045 and 1.287 at pH 3 and 7 respectively. The Pow values of test material at pH 3 and 7 were 1116 and 19.42, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
