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EC number: 696-231-5 | CAS number: 1361000-03-4
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The Partition Coefficient (n-octanol/water), log Pow, of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate at ambient temperature was 3.045 and 1.287 at pH 3 and 7 respectively (measured by the HPLC method OECD 117).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.287
- at the temperature of:
- 20 °C
Additional information
The Partition Coefficient of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate was determined according to the OECD 117 guideline (Partition Coefficient (n-octanol/water) using High Performance Liquid Chromatography (HPLC) and following GLP.
The test was conducted with a test material concentration of 4 mg/L in mobile phase consisting of methanol and HPLC water (65:35 v/v) (with potassium phosphate salts). The experiment was performed at two different pH conditions (pH 3 and 7) and at ambient temperature. Samples of the test material were analyzed via HPLC.
Calibration was performed using eight reference materials. Dead time of the HPLC-system was determined three fold using 0.1 mL of thiourea in mobile phase.
The Partition Coefficient (n-octanol/water), log Pow, of 1-hexyl-1H-pyrazol-4,5-diamine hemisulfate was 3.045 and 1.287 at pH 3 and 7 respectively. The Pow values of test material at pH 3 and 7 were 1116 and 19.42, respectively.
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