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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015-02-12
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Temp.:
20 °C
Vapour pressure:
0 hPa
Remarks on result:
other: extrapolated from the experimental data
Key result
Temp.:
25 °C
Vapour pressure:
0 hPa
Remarks on result:
other: extrapolated from the experimental data
Temp.:
50 °C
Vapour pressure:
0 hPa
Remarks on result:
other: extrapolated from the experimental data
Conclusions:
The vapour pressure was determined in a GLP guideline study according to OECD 104, and EU method A.4 without deviations on the registered substance itself. Hence, there is no indication given that the results are not reliable. Vapour pressure (extrapolated from experimental data) = 4.3×10^-7 hPa at 20 °C, 6.2×10^-7 hPa at 25 °C and 3.5× 10^-6 hPa at 50 °C
Executive summary:

The vapour pressure of the test substance was determined in a GLP study according to OECD 104 and EU Method A.4 using the effusion method: vapour pressure balance. Vapour pressure was measured in the temperature range of 50 °C to 100 °C in intervals of 10 K.

The following vapour pressure values for the test item were extrapolated from experimental data:

T [°C]

p [hPa]

p [Pa]

20

4.3 ×10-7

4.3 × 10-5

25

6.2 × 10-7

6.2 × 10-5

50

3.5 × 10-6

3.5 × 10-4

Description of key information

vapour pressure (extrapolated from experimental data) = 4.3×10^-7 hPa at 20 °C, 6.2×10^-7 hPa at 25 °C and 3.5× 10^-6 hPa at 50 °C 

Key value for chemical safety assessment

Vapour pressure:
0 hPa
at the temperature of:
25 °C

Additional information

Vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25 °C.

The GLP study was performed according to OECD TG104 and EU Method A.4 without deviations and therefore reliability of Klimisch 1 has been assigned.