Registration Dossier
Registration Dossier
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EC number: 216-323-7 | CAS number: 1559-35-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- This study was conducted in the early days of GLP and prior to guidelines, but was done at a highly reputible laboratory. So extensive details are missing, but there is no reason to question the quality and the results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- At this time, studies conducted at the Kodak laboratory used an in-house protocol similar to OECD 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-[(2-ethylhexyl)oxy]ethanol
- EC Number:
- 216-323-7
- EC Name:
- 2-[(2-ethylhexyl)oxy]ethanol
- Cas Number:
- 1559-35-9
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 2-[(2-ethylhexyl)oxy]ethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- No description is available. The standard method was to test the substance as marketed at the time
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- None given
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Not provided
- Doses:
- Not provided
- No. of animals per sex per dose:
- Not provided
- Control animals:
- not specified
- Details on study design:
- Not provided
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 674 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: fasted rats
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 169 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Fed animals
- Clinical signs:
- other: slight to severe weakness, inactivity, depression, prostration, labored breathing, anorexia, reddish deposit around eyes, nose and mouth and death.
- Gross pathology:
- Not provided
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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