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EC number: 270-180-5 | CAS number: 68412-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based upon available information.
- Adequacy of study:
- key study
- Study period:
- March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information selected for the toxicokinetic assessment is primarily study data. Studies were conducted inaccordance with recognised testing guidelines.
Data source
Reference
- Reference Type:
- other: Assessment
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Results and discussion
Any other information on results incl. tables
The physical state of the substance, molybdenum, bis(dibutylcarbamodithioato)di-mu-oxodioxodi-, sulfurizedis, yellow powder with 38.6% of particles less than 100 μm and 0.012% of particles less than 10 μm in size. The particle size of the substance indicates that the majority of the substance particles are not respirable and, therefore, the substance is unlikely to be absorbed via the inhalation route.
The water solubility and partition coefficient (Log Pow)of the substance are 0.0528 mg/L and 6.24 -7.28, respectively. The typical molecular mass of the substance (C18H36N2Mo2O4S4) is 664.63 daltons. These data indicate that the substance is relatively large (> 500 daltons), has very low water solubility (<0.1 mg/L), and is a highly lipophilic (Log Pow > 5.6) molecule, and thus is not expected to be absorbed via the oral route, in accordance with Lipinski's rule of five. Furthermore, acute and repeated dose oral toxicity studies in rats did not show any systemic effects up to the highest doses tested (2000 mg/kg in the acute oral toxicity study and 1000 mg/kg/day in the combined repeated dose oral toxicity study with the reproductive/developmental toxicity screening test). No information is currently available on possible degradation products produced in the gastrointestinal tract. The very low water solubility, high lipophilicity, and relatively large molecular mass of the substance also indicate that it is not expected to be absorbed via the dermal route. Thelocal lymph node assay in mouse and skin irritation test in vitroshowed that the substance is neither a skin sensitizer nor a skin irritant.
Additionally, the ready biodegradability test of the substance showed that it was not readily biodegradable. Although the Log Pow of the substance exceeds 5, its water solubility is very low, and thus, the substance is expected to have low potential for bioaccumulation in aquatic organisms.
In conclusion, based upon the available data,the substance, molybdenum, bis(dibutylcarbamodithioato)di-mu-oxodioxodi-, sulfurizedis not expected to be bioavailable and has low or no systemic toxicity.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, based upon the available data,the substance, molybdenum, bis(dibutylcarbamodithioato)di-mu-oxodioxodi-, sulfurizedis not expected to be bioavailable and has low or no systemic toxicity.
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