Registration Dossier
Registration Dossier
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EC number: 203-310-6 | CAS number: 105-57-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 937
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Determination of the acute oral toxicity in rabbits.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- 1,1-diethoxyethane
- EC Number:
- 203-310-6
- EC Name:
- 1,1-diethoxyethane
- Cas Number:
- 105-57-7
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 1,1-diethoxyethane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 15, 20, 25, 28.5, and 30 mmol/kg bw
- No. of animals per sex per dose:
- 5 - 8
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 360 - < 3 540 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 - < 30 other: mmol/kg
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
In the review article, an LD50 range between 2360 and 3540 mg/kg bw for the acute oral toxicity of the test item in rabbits is reported.
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