Registration Dossier
Registration Dossier
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EC number: 200-955-5 | CAS number: 76-37-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure
- Author:
- Izmerov N.F. et al.
- Year:
- 1 982
- Bibliographic source:
- Moscow, Centre of International Projects, GKNT, 1982, Pg. 109, 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: not reported
Test material
- Reference substance name:
- 2,2,3,3-tetrafluoropropan-1-ol
- EC Number:
- 200-955-5
- EC Name:
- 2,2,3,3-tetrafluoropropan-1-ol
- Cas Number:
- 76-37-9
- Molecular formula:
- C3H4F4O
- IUPAC Name:
- 2,2,3,3-tetrafluoropropan-1-ol
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no details reported
Administration / exposure
- Route of administration:
- other: not specified
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not reported
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Concentrations:
- not reported
- No. of animals per sex per dose:
- not reported
- Control animals:
- not specified
- Details on study design:
- no details reported
- Statistics:
- not reported
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 8 600 mg/m³ air
- Exp. duration:
- 2 h
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 4.3 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- not measured/tested
- Remarks:
- extrapolated using Haber's c x t law
- Mortality:
- not reported
- Clinical signs:
- other: not reported
- Body weight:
- not reported
- Gross pathology:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Using Haber's law, the 4-h LC50 is predicted to be 4.3 mg/L.
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