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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Single administration; observation 14 days or until animals appeared normal
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Justification for type of information:
Although study done to guidelines current at the time, the report is sparce with limited details.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
other: Limit test
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-Propanaminium, 3,3',3''-[phosphinylidynetris(oxy)]tris[N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-, N,N',N''-tri-C6-18 acyl derivs. trichlorides
EC Number:
280-518-3
EC Name:
1-Propanaminium, 3,3',3''-[phosphinylidynetris(oxy)]tris[N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-, N,N',N''-tri-C6-18 acyl derivs. trichlorides
Cas Number:
83682-78-4
IUPAC Name:
1-Propanaminium, 3,3',3''-[phosphinylidynetris(oxy)]tris[N-(3-aminopropyl)-2-hydroxy-N,Ndimethyl-, N,N',N''-tri-C6-18 acyl derivs, trichlorides
Specific details on test material used for the study:
Described as Lot 2512

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
Single dose 5 ml/kg of material as supplied (ca 40% actives)
No. of animals per sex per dose:
Five
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 2 000 mg/kg bw
Based on:
act. ingr.
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 5 000 mL/kg bw
Based on:
test mat.
Remarks:
Supplied as nominal 40%
Mortality:
No
Clinical signs:
other: Lethargy and loose stools in several animals for up to 24 hours post treatment

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Material was tolerated at maximum treated dose level.