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EC number: 947-394-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11th January - 21st February, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- Commission Directive 92/69/EEC
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fatty acids, C12-18, α-sulfo, 1-Me esters, sodium salts
- EC Number:
- 288-224-7
- EC Name:
- Fatty acids, C12-18, α-sulfo, 1-Me esters, sodium salts
- Cas Number:
- 85681-86-3
- Molecular formula:
- C13H25NaO5S - C19H37NaO5S
- IUPAC Name:
- Fatty acids, C12-18, α-sulfo, 1-Me esters, sodium salts
- Reference substance name:
- Fatty acids, C12-18, α-sulfo, disodium salts
- EC Number:
- 286-085-7
- EC Name:
- Fatty acids, C12-18, α-sulfo, disodium salts
- Cas Number:
- 85186-99-8
- Molecular formula:
- C12H22Na2O5S - C18H34Na2O5S
- IUPAC Name:
- Fatty acids, C12-18,α-sulfo, disodium salts
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Blackthorn, Bicester, Oxon, UK
- Females (if applicable) nulliparous and non-pregnant: No data
- Age at study initiation: 5-8 weeks old
- Weight at study initiation: males 134-148g; females 124-132 g.
- Fasting period before study: Overnight fast immediately before dosing
- Housing: Housed in groups of up to five by sex in solid floor polypropylene cages furnished with woodflakes.
- Diet: ad libitum from 2 hours after dosing. Rat and Mouse Expanded Diet No. 1,
- Water: ad libitum from 2 hours after dosing
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): 38-69
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION (if unusual):The test material was ground to a fine powder using a mortar and pestle and freshly prepared, as required, as a solution/suspension at the appropriate concentration in DMSO. Homogeneity was assured by the use of a Silverson Homogeniser.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Not applicable - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for deaths or overt signs of toxicity 1/2, 1, 2 and 4 hours after dosing and subsequently once daily for 14 days. Individual bodywieghts were recorded prior to dosing on Day 0 and on Days 7 and 14 or at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology (external examination and opening of the abdominal and thoracic cavities). - Statistics:
- Not stated
Results and discussion
- Preliminary study:
- The female was found dead one day after dosing. No clinical signs of toxicity were noted.
Based on this information, a dose level of 2000 mg/kg bw was selected for the main study.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable
- Mortality:
- Two females were found dead one day after dosing.
- Clinical signs:
- other: Common signs of systemic toxicity noted were hunched posture, lethargy, decreased respiratory rate and laboured respiration with additional signs of noisy respiration and increased salivation. Surviving animals recovered two to four days after dosing.
- Gross pathology:
- Abnormalities noted at necropsy of the females that died during the study were haemorrhagic lungs, dark liver, dark kidneys, haemorrhage of the gastric mucosa and hamorrhage fo the small and large intestines. Sloughing of the gastric mucosa was noted at necropsy of one male and one female that were killed at the end of the study. No abnormalities were noted at necropsy of all other animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item was > 2000 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test item was assessed in a study performed according to OECD TG 401 and Method B.1 of Commission Dreictive 67/548/EEC using Sprague-Dawley rats. In a preliminary test, 2 rats (one male/one female) were dosed by gavage at 2000 mg/kg bw. The female was found dead one day after dosing. No clinical signs of toxicity were noted. Based on this information, a dose level of 2000 mg/kg bw was selected for the main study. Based on the results of this test, rats (5 males and 5 females) were dosed by gavage at 2000 mg/kg bw/day and observed for 14 days. Two females were found dead one day after dosing. No further deaths were recorded. Common signs of systemic toxicity noted were hunched posture, lethargy, decreased respiratory rate and laboured respiration with additional signs of noisy respiration and increased salivation. Surviving animals recovered two to four days after dosing. Surviving animals showed expected bodyweight gain during the study. Abnormalities noted at necropsy of the females that died during the study were haemorrhagic lungs, dark liver, dark kidneys, haemorrhage of the gastric mucosa and hamorrhage of the small and large intestines. Sloughing of the gastric mucosa was noted at necropsy of one male and one female that were killed at the end of the study. No abnormalities were noted at necropsy of all other animals that were killed at the end of the study. Based on the results of this study, the oral LD50 was determined to be >2000 mg/kg bw.
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