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Environmental fate & pathways

Biodegradation in water: screening tests

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biodegradation in water: ready biodegradability
Type of information:
Adequacy of study:
supporting study
Study period:
(January 2017)
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Materials and methods

Principles of method if other than guideline:
QSAR EPI Suite (v4.11) - Probability of Rapid Biodegradation (BIOWIN v4.10)
GLP compliance:

Results and discussion

Any other information on results incl. tables

The QSAR predictions using BIOWIN, part of the USEPA EPisuite software, is below.  It concludes that it is non-readily biodegradation based on all 7 tools.


Probability of Rapid Biodegradation (BIOWIN v4.10):

   Biowin1 (Linear Model)         :  -1.3441

   Biowin2 (Non-Linear Model)     :   0.0000

Expert Survey Biodegradation Results:

   Biowin3 (Ultimate Survey Model):   0.1277  (recalcitrant)

   Biowin4 (Primary Survey Model) :   1.8148  (months      )

MITI Biodegradation Probability:

   Biowin5 (MITI Linear Model)    :   0.0932

   Biowin6 (MITI Non-Linear Model):   0.0000

Anaerobic Biodegradation Probability:

   Biowin7 (Anaerobic Linear Model): -1.1444

Ready Biodegradability Prediction:   NO

Applicant's summary and conclusion

Interpretation of results:
not readily biodegradable
Based on its structural properties, the estimated probability of primary or ultimate degradation of PFOB during waste water treatment was low; PFOB is predicted to be recalcitrant. PFOB is not predicted to be readily biodegradable.