Registration Dossier
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EC number: 267-744-8 | CAS number: 67914-60-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 March 2016 - 24 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Batch n°: I15FB3131
- Analytical purity: 100% (Based on base titration assay)
- Expiration date: 11 June 2017
- Storage condition: at room temperature - Key result
- Water solubility:
- 3.35 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- concentration analysed after centrifugation
- Loading of aqueous phase:
- 17.7 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 6.9
- Details on results:
- Preliminary test
The content of test item dissolved in the water sample was 3.23, 3.32, 3.39 and 3.83 g/L after 1, 3, 6 and 72h of stirring.
Main test
The results for the samples taken at 24, 48 and 72 hours are given in the table in the next section. The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analysed concentrations.
No test item was detected in the pretreated sample from the blank water mixture. - Conclusions:
- The flask method was applied for the determination of the water solubility of JNJ-119379-AAA (T001141).
The water solubility of the test item at 20°C was 3.35 g/L.
The pH of the aqueous samples was 6.4 – 6.9.
Reference
The results for the samples taken at 24, 48 and 72 hours are given in the table underneath.
| Stirring time (hours) | Analysed concentration (g/L) | Mean (g/L) | Maximum Difference (MD) (%) | pH |
| 24 | 3.18 | 3.35 | 8.7 | 6.9 |
| 48 | 3.47 | 6.4 | ||
| 72 | 3.39 | 6.7 |
Description of key information
The water solubility of T001141 was determined in a GLP study performed according to the OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840 (Klimisch 1, Reingruber, 2017) using the flask method and was determined to be 3.35 g/L at 20°C and pH 6.4 - 6.9.
Key value for chemical safety assessment
- Water solubility:
- 3.35 g/L
- at the temperature of:
- 20 °C
Additional information
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