Registration Dossier
Registration Dossier
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EC number: 259-709-0 | CAS number: 55566-30-8
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
A Log Pow value of minus 9.8 has been obtained by calculation (Safepharm
Laboratories (1997).
Indeed THPS main ingredient is infinitely soluble in water and is an
ionised substance.
Log Pow measurements by the HPLC method and by the shake flask method
are not applicable to substances which have a log Pow < 0 and < -2
respectively. Therefore only a calculated value can be provided.
Effect of pH (5 to 9) and temperature is not expected as THPS main
ingredient is ionised and infinitely soluble in water at these pH and at
environmentally relevant temperatures.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -9.8
Additional information
One non-GLP study performed according to standard guideline was disregarded (reliability 3) because the HPLC method used is not applicable to substances which have a log Pow<0.
One non-GLP study performed according to a scientifically valid shake flask method was disregarded (reliability 3) because the method is not applicable to substances of very high solubility in water and no result was obtained in the study report.
Log Pow was calculated with the KOWWIN program based on the method described in the literature (HOWARD P.H. and MEYLAN W.M., J. Pharm. Sci., 84 (1) : 83-92, 1995). This accepted calculation method gives a log P = - 9.8 for THPS, which is then considered to have no potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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