Dirhodium trisulphate

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

no data

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Case report on only one individual, with limited reporting

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Occupational contact dermatitis caused by rhodium

Author:

Gomez de la Fuente E, Alvarez JG, Vicente FJ, Sols M, Naz E and Lopez-Estebaranz JL

Year:

2003

Bibliographic source:

American Journal of Contact Dermatitis 14, 172-175

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Principles of method if other than guideline:

Patch test performed on an individual with occupationally-associated dermatitis.

GLP compliance:

not specified

Remarks:

not applicable

Test material

Test material information

Constituent 1

Reference substance name:

rhodium sulfate

IUPAC Name:

rhodium sulfate

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): rhodium sulfate
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data

Method

Type of population:

occupational

Ethical approval:

not specified

Subjects:

- Number of subjects exposed: 1
- Sex: female
- Age: 59
- Race: no data

Clinical history:

- History of allergy or casuistics for study subject: no significant previous clinical history.
- Symptoms, onset and progress of the disease: 2-year pruriginous erythematous dermatitis on fingers and forearms, predominantly on first three digits of each hand
- Exposure history: worked in a goldsmith's workshop for 10 years, using an electrogalvanic device with a rhodium sulfate solution in dilute sulfuric acid (rhodium concentration 2.75 g/l).
- Aggravating factors both in home and workplace: Handled several metals including gold, silver, platinum, nickel and chromium. Dermatitis was said to improve upon absence from work for several weeks.
- Family history: no data
- Any other allergic or airway disorders: no data
- Smoking history: no data

Controls:

None.

Route of administration:

dermal

Details on study design:

TYPE OF TEST(S) USED: patch test (epicutaneous test) with the Spanish Group for Research of Contact Dermatiis (GEIDC) series and a "metal series" from Chemotechnique Diagnostics (Malmo, Sweden) [nether series was further defined].

ADMINISTRATION
- Type of application: no data
- Description of patch: no data
- Vehicle / solvent: no data
- Concentrations: 2%
- Volume applied: no data
- Testing/scoring schedule: reactions read at 2 and 4 days [it is not clear whether this is after patch application or removal]
- Removal of test substance: no data

EXAMINATIONS
- Grading/Scoring system: including "++"; not further defined
- Statistical analysis: no data

Results and discussion

Results of examinations:

SYMPTOMS
- A reaction indicative of skin sensitisation was seen (positive, "++", not further defined, at days 2 and 4) for rhodium sulfate only.

RESULT OF CASE REPORT: after avoiding contact with rhodium solution, and protecting hands with gloves, great improvement was seen in the dermatitis. Occasional contact resulted in relapse of symptoms.

Applicant's summary and conclusion

Conclusions:

A case study reports an individual with occupational exposure to a rhodium sulfate solution, and a concurrent history of work-related dermatitis, displaying a reaction indicative of skin sensitisation following patch-testing with 2% rhodium sulfate.

Executive summary:

A case report describes an individual with occupational exposure to a rhodium sulfate solution, and a concurrent history of work-related dermatitis.

 

A patch test with 2% rhodium sulfate, applied to the skin of the patient for an unspecified amount of time with reactions read after 2 and 4 days, indicated skin sensitisation. Dermatitis symptoms improved after changing working habits to avoid contact with rhodium sulfate.