Registration Dossier
Registration Dossier
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EC number: 431-020-1 | CAS number: 41340-36-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(7-ethyl-1H-indol-3-yl)ethanol
- EC Number:
- 431-020-1
- EC Name:
- 2-(7-ethyl-1H-indol-3-yl)ethanol
- Cas Number:
- 41340-36-7
- Molecular formula:
- C12H15NO
- IUPAC Name:
- 2-(7-ethyl-1H-indol-3-yl)ethan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: bi-distilled water
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- mean score 1,2,3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- mean score 1,2,3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
No clinical signs of systemic toxicity were observed in the animals during the test and observation period, and no mortality occured.
No signs of irritation were observed.
Reversible light brown staining by the test article of the treated skin was observed in all animals until 24 hours after treatment.
The body weight of all rabbits were considered to be within the normal range of variability.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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