Registration Dossier
Registration Dossier
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EC number: 287-791-8 | CAS number: 85585-89-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- EC Number:
- 287-791-8
- EC Name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- Cas Number:
- 85585-89-3
- Molecular formula:
- C18H11CuKN2Na2O14S4
- IUPAC Name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- Test material form:
- solid
- Details on test material:
- Reactive Red 23
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Silver Yellow
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: one per cage
- Diet: Altromin standard diet ad libitum
- Water: mains water ad libitum
Test system
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1mL of 10% test item in water
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- observation after 1, 3, 7 and 24h after application
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 3, 7 and 24h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 3, 7 and 24h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 3, 7 and 24h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1, 3, 7 and 24h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test item is not irritating to eyes in a 10% aqueous solution.
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