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Registration Dossier
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EC number: 287-791-8 | CAS number: 85585-89-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- Barail-Test:
intracutaneous injection of an aqueous solution (1) or application on depilated skin (2) - GLP compliance:
- no
Test material
- Reference substance name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- EC Number:
- 287-791-8
- EC Name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- Cas Number:
- 85585-89-3
- Molecular formula:
- C18H11CuKN2Na2O14S4
- IUPAC Name:
- Cuprate(3-), [3-hydroxy-4-[[2-hydroxy-5-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2,7-naphthalenedisulfonato(5-)]-, potassium sodium
- Test material form:
- solid
- Details on test material:
- Reactive Red 23
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Silver Yellow
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: one per cage
- Diet: Altromin standard diet ad libitum
- Water: mains water ad libitum
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes
- Amount / concentration applied:
- (1) injection of 0.02mL of 10, 1, 0.1 and 0.01% test item in water
(2) application of 0.5mL of 10% test item in water on depilated skin - Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no irritant effects were observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test substance is determined as not irritating to rabbit skin.
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