Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-983-7 | CAS number: 28348-53-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna; age of neonates was less than 24 h
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 140-160 mg/L (as CaCO3)
- Test temperature:
- 20 +/- 1 deg C
- pH:
- 8.5 +/- 0.2
- Reference substance (positive control):
- not specified
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 30 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- reproduction
- Remarks on result:
- other: number of offspring
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 154 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- reproduction
- Remarks on result:
- other: number of offspring
- Details on results:
- The 21-day NOEC for Daphnia magna was >30 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 21-day NOEC for Daphnia magna was >30 mg/L
Reference
There was no significant test substance related mortality of parent animals. The average number of offspring produced per day was 43 in the controls, 38 at 30 mg/L, 29 at 100 mg/L and 13 at 300 mg/L which equates to 88%, 67% and 30% of control response, respectively.
Description of key information
The 21-day NOEC for Daphnia magna was >30 mg/L for sodium cumenesulphonate
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 30 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 3 mg/L
Additional information
The available data for saltwater invertebrates a are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to NOEC following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
