Registration Dossier
Registration Dossier
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EC number: 303-085-5 | CAS number: 94158-14-2
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- 2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
- EC Number:
- 303-085-5
- EC Name:
- 2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
- Cas Number:
- 94158-14-2
- Molecular formula:
- C9H11NO3.ClH
- IUPAC Name:
- 2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride
- Test material form:
- solid: crystalline
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 25 °C
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- 1.14 dimensionless
- pH:
- 9
- Temp.:
- 25 °C
- Sample No.:
- #2
- Type:
- Koc
- Value:
- 14.1 dimensionless
- Sample No.:
- #3
- Type:
- Koc
- Value:
- 13.5 dimensionless
- Sample No.:
- #4
- Type:
- Koc
- Value:
- 13.5 dimensionless
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated value of log Koc for the test item AMINOL was determined to be 1.14 ± 0.012 corresponding to a Koc of 13.7.
Acc. to the MCCALL-classification scheme of soil mobility potential a Koc of 13.7 would mean very high mobility for AMINOL in soil. - Executive summary:
The estimation of the adsorption coefficient (Koc) on soil and on sewage sludge using high performance liquid chromatography (HPLC) was carried out according to the principles of OECD/OCDE-Guideline No. 121 (adopted 2001-01-22) for the test item AMINOL (batch number: R0075037) on 2003-06-11 at the DR.U.NOACK·lABORATORIEN, Sarstedt, Germany. The test was conducted with a test item concentration of 5 mg/L in mobile phase of 45 % acetonitrile and 55 % borate-buffer pH 9.0. Samples of the test item AMINOL were analysed threefold via HPLC on a cyanopropyl (CN-) column with UV - detection. Calibration was performed using six reference items with known values of log Koc (values from batch equilibrium experiments given in literature), each with a nominal concentration of 5 mg/L in mobile phase. Analysis of the reference items were performed once before and after analysis of test item, respectively. Dead time of the HPLC-system was determined threefold using 5 mg/L sodium nilrate in mobile phase. For calibration data and details see part 4.2.
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