Registration Dossier
Registration Dossier
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EC number: 251-823-9 | CAS number: 34090-76-1
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity studies have been undertaken on a structural analogue of the substance, MTHPA.
In the algae growth inhibition test [OECD TG201], an EC50 (72 hours) of 68 mg/L (Selenastrum capricornutum, growth rate 24 -72hours) and 64 mg/L (biomass, 72 hours) were reported and the NOEC value determined was 27.5 mg/L (growth rate, 24 -72 hours and biomass, 72 hours). In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, the ErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
In the water flea test, the acute EC50 (48 hours) value for immobility to Daphnia magna [OECD TG 202 part 2] was 130 mg/L. In a chronic daphnia reproduction test [OECD TG 211] the EC50 (21 day, reproduction) was greater than 40 mg/L and the NOEC (21 day, reproduction) was 20 mg/L. It is suggested that a part of the toxicity to green algae and water fleas is due to acidity.
The LC50 value for acute toxicity and prolonged toxicity to fish (Medaka) were reported as greater than 100 mg/L [OECD TG 203] (96 hr) and greater than 100 mg/L [OECD TG 204](14 day).
In the microorganisms test, the EC50 value was 69.87mg/L [OECD TG 209].
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