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Description of key information

Hydrolysis: Half life of minutes at all three temperatures tested (5, 20, 25 degree C) at pH 4, pH 7 and pH 9.

Key value for chemical safety assessment

Half-life for hydrolysis:
3.2 min
at the temperature of:
20 °C

Additional information

Hydrolysis of a structural analogue of the substance, tetrahydromethylphthalic anhydride (MTHPA), has been investigated in accordance with OECD test methods. A pre-test showed the substance to be rapidly hydrolysed at pH 4, 7 and 9.

In the key study, the main hydrolysis study, HPLC-UV analysis measured decreasing MTHPA concentrations as a function of hydrolysis over time. MTHPA was found to hydrolyse fast resulting in formation of the respective di-acid. The calculated half-lives at 20 degree C are for all three pH values below 3.5 minutes (about 0.06 hours).