Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: Assessment
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Report date:
2013

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Assessment of physico-chemical and toxicological parameters, including evidence of sytemic activity
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-o-tolylbiguanide
EC Number:
202-268-6
EC Name:
1-o-tolylbiguanide
Cas Number:
93-69-6
Molecular formula:
C9H13N5
IUPAC Name:
1-o-tolylbiguanide
Radiolabelling:
no

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
No evidence of systemic effects and absorption cannot be demonstrated
Details on distribution in tissues:
No evidence of systemic effects and distribution cannot be demonstrated
Details on excretion:
No evidence of systemic effects and excretion cannot be demonstrated

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
There is no clear evidence for toxicokinetics from the data provided, but evaluation of this class of substances suggests that absorption could occur from ingestion, but there would be reasonably fast metabolic breakdown and excretion. The substance is unlikely to accumulate in fat or target organs.