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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
5.88 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEC
Value:
1 763 mg/m³
Explanation for the modification of the dose descriptor starting point:

Table 8.6 in guidance r8

AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for differences in duration of exposure:
6
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
4
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
2.5
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
1
Justification:
Table 8.6 in guidance r8
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
35.26 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
50
Modified dose descriptor starting point:
NOAEC
Value:
1 763 mg/m³
Explanation for the modification of the dose descriptor starting point:

Based on Chapter R.8: Characterisation of dose [concentration]-response for human health Appendix R.8-2

AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
5.88 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
300
Dose descriptor:
NOAEC
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for differences in duration of exposure:
6
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
4
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
2.5
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
1
Justification:
Table 8.6 in guidance r8
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
35.26 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
50
Dose descriptor starting point:
NOAEC
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
50
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
55.6 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
50
Modified dose descriptor starting point:
NOAEL
Value:
2 780 mg/kg bw/day
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
55.6 mg/cm²
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
50
Dose descriptor starting point:
other: NOAEL
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
5
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.47 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
600
Modified dose descriptor starting point:
NOAEC
Value:
882 mg/m³
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for differences in duration of exposure:
6
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
4
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
2.5
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
1
Justification:
Table 8.6 in guidance r8
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
8.82 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
100
Modified dose descriptor starting point:
NOAEC
Value:
870 mg/m³
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.47 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
600
Dose descriptor:
NOAEC
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for differences in duration of exposure:
6
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
4
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
2.5
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
1
Justification:
Table 8.6 in guidance r8
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
8.82 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
100
Dose descriptor starting point:
NOAEC
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
27.8 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
100
Modified dose descriptor starting point:
NOAEL
Value:
2 780 mg/kg bw/day
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
27.8 mg/cm²
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
100
Dose descriptor starting point:
other: NOAEL
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.67 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
600
Modified dose descriptor starting point:
NOAEL
Value:
1 000 mg/kg bw/day
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for differences in duration of exposure:
6
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
4
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
2.5
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
1
Justification:
Table 8.6 in guidance r8
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
10 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
100
Modified dose descriptor starting point:
NOAEL
Value:
1 000 mg/kg bw/day
AF for dose response relationship:
1
Justification:
Table 8.6 in guidance r8
AF for interspecies differences (allometric scaling):
1
Justification:
Table 8.6 in guidance r8
AF for other interspecies differences:
4
Justification:
Table 8.6 in guidance r8
AF for intraspecies differences:
10
Justification:
Table 8.6 in guidance r8
AF for the quality of the whole database:
1
Justification:
Table 8.6 in guidance r8
AF for remaining uncertainties:
2.5
Justification:
Table 8.6 in guidance r8

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - General Population