Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1989
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Succinonitrile
EC Number:
203-783-9
EC Name:
Succinonitrile
Cas Number:
110-61-2
Molecular formula:
C4H4N2
IUPAC Name:
butanedinitrile
Details on test material:
- Analytical purity: 97%
- Source: Aldrich Chemical Company, Milwaukee, WI, USA

Results and discussion

Applicant's summary and conclusion

Conclusions:
Based on this ex vivo study, it can be concluded that succinonitrile can be metabolized to cyanide in the nasal tissue and -to a lesser extent- in the liver.
Executive summary:

In a microsomal enzyme assay it was shown that succinonitrile is metabolized to cyanide. Microsomal fractions from both nasal and liver preparations actively metabolized succinonitrile to cyanide.