Registration Dossier
Registration Dossier
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EC number: 203-783-9 | CAS number: 110-61-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Succinonitrile
- EC Number:
- 203-783-9
- EC Name:
- Succinonitrile
- Cas Number:
- 110-61-2
- Molecular formula:
- C4H4N2
- IUPAC Name:
- butanedinitrile
- Details on test material:
- - Analytical purity: 97%
- Source: Aldrich Chemical Company, Milwaukee, WI, USA
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Based on this ex vivo study, it can be concluded that succinonitrile can be metabolized to cyanide in the nasal tissue and -to a lesser extent- in the liver.
- Executive summary:
In a microsomal enzyme assay it was shown that succinonitrile is metabolized to cyanide. Microsomal fractions from both nasal and liver preparations actively metabolized succinonitrile to cyanide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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