2-Propenamide, N-[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]-2-methyl-

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 March 2017- 11 April 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

May 31, 2008

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

Juy 27, 1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Version / remarks:

August 1996

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-methylprop-2-enamide

EC Number:

611-915-5

Cas Number:

59941-98-9

Molecular formula:

C16 H18 N4 O3 S

IUPAC Name:

N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-methylprop-2-enamide

Test material form:

solid: particulate/powder

Remarks:

white crystalline

Results and discussion

Boiling point

Key result

Decomposition:

yes

Remarks:

Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting.

Remarks on result:

not determinable

Remarks:

Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.

Any other information on results incl. tables

Preliminary Test

Starting at 315°C, the weight of the sample decreased significantly. At 342°C, the sample weight had decreased by 25%.

After the experiment, a black molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

Main Study

An endothermic peak was observed between 200°C and 250°C. The extrapolated onset temperature of the peak was 237.431°C. The endothermic effect was most likely obtained due to melting of the test item. An exothermic peak was observed between 275°C and 342°C. The exothermic effect was due to reaction and/or decomposition of the test item.

After the experiment, a brown/black molten residue remained in the sample container.

In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak. The extrapolated onset temperature was 237.051°C. After the experiment, a light yellow molten residue remained in the sample container (original colour: white) container. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

The melting temperature was determined as the mean melting temperature of Experiment 1 (237.431°C) and Experiment 2 (237.051°C)

Applicant's summary and conclusion

Conclusions:

The melting and boiling temperature of V123109 were determined by DSC.
The melting temperature of the test item was 237.2°C (510.4K). The estimated accuracy, according to the OECD Guideline 102 , for this method is ± 0.5°C.
Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.