Registration Dossier
Registration Dossier
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EC number: 203-898-4 | CAS number: 111-71-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Maximization Test: The material was applied under occlusion for five alternate-day 48 hour periods.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Heptanal
- EC Number:
- 203-898-4
- EC Name:
- Heptanal
- Cas Number:
- 111-71-7
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptanal
- Details on test material:
- - Name of test material (as cited in study report): RIFM 74-4-12
- Substance type: aldehyde C 7
- Physical state: no data
- Analytical purity: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Method
- Type of population:
- not specified
- Controls:
- no data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- The test material produced no intances of contact-sensitization.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test, heptanal induced no instances of contact-sensitization.
- Executive summary:
To determine the contact-sensitizing potential of heptanal, 25 healthy adult volunteers were exposed to the material under occlusion for five alternate-day 48 hour periods. The patch sites were pre-treated for 24 hours with 5 % aqueous sodium lauryl sulfate under occlusion. The challenge sites were read on removal of the patch and 24 hours thereafter. Under the conditions of this test, heptanal induced no instances of contact-sensitization.
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