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EC number: 305-897-5 | CAS number: 95193-83-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of the test chemical
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 019
- Bibliographic source:
- WoE report, Sustainability Support Services (Europe) AB, 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Acute dermal toxicity study was performed to determine the toxic nature of the test chemical
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1H-Indene-1,3(2H)-dione, 2-(2-quinolinyl)-, sulfonated, sodium salts
- EC Number:
- 305-897-5
- EC Name:
- 1H-Indene-1,3(2H)-dione, 2-(2-quinolinyl)-, sulfonated, sodium salts
- Cas Number:
- 95193-83-2
- Molecular formula:
- C18H11NO5S to C18H8NO11S3.3Na
- IUPAC Name:
- trisodium hydrogen bis(2-(1,3-dioxo-5-sulfonato-2,3-dihydro-1H-inden-2-yl)quinoline-8-sulfonate)
- Details on test material:
- - Name of the test chemical: 1H-Indene-1,3(2H)-dione, 2-(2-quinolinyl)-, sulfonated, sodium salts
- Molecular formula: C18H9NNa2O8S2
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- 14 days
- Doses:
- 2. 2000 mg/Kg bw
3. 5000 mg/Kg - No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- 2. - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, gross-pathology
3. - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: No data - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed at the mentioned dose
- Remarks:
- 2
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed at the mentioned dose
- Remarks:
- 3
- Mortality:
- 2. No mortality was observed at 2000 mg/Kg bw
3. 50% mortality was observed at approximately 5000 mg/Kg bw - Clinical signs:
- other: 2. GASTROINTESTINAL: Hypermotility, diarrhea 3. No data
- Gross pathology:
- 2. LIVER: Other changes;
KIDNEY, URETER, AND BLADDER: Other changes;
3. No data - Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal median lethal dose (LD50) for the test chemical using rabbits is considered to be > 2000 mg/Kg bw.
- Executive summary:
Data available for the various test chemicals was reviewed to determine the toxic nature of the test chemical. The studies are as mentioned below:
Acute dermal toxicity study was performed to determine the toxic nature of the test chemical. The study was performed using rabbits at dose of 2000 mg/Kg bw. The treated animals were observed for clinical signs and subjected to gross pathology. Hypermotility and diarrhea was noted in the gastrointestinal tract and few other changes were observed in liver, kidneys, ureter and bladder. No mortality was noted at dose of 2000 mg/Kg bw. Based on the results of the study, the acute dermal median lethal dose (LD50) for the test chemical using rabbits is considered to be >2000 mg/Kg bw.
Acute dermal toxicity study was performed to determine the toxic nature of the test chemical. The study was performed using rabbits at dose of 5000 mg/Kg bw. The treated animals were observed for mortality. 50% mortality was noted at approximately 5000 mg/Kg bw. Based on the results of the study, the acute dermal median lethal dose (LD50) for the test chemical using rabbits is considered to be approximately 5000 mg/Kg bw.
Based on the data available and applying the weight of evidence approach, the acute dermal median lethal dose (LD50) for the test chemical using rabbits is considered to be > 2000 mg/Kg bw.
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