Registration Dossier
Registration Dossier
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EC number: 241-010-7 | CAS number: 16941-12-1
Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
Description of key information
The 72-hour EC50 for biomass and growth rate were estimated to be 1.32 mg Pt L-1and 3.30 mg Pt L-1, respectively. The 72-hour NOEC was determined to be 0.209 mg Pt L-1based on biomass and 0.62 mg Pt L-1based on growth rate. The 72-hour LOEC values for biomass and growth rate were determined to be 0.62 mg Pt L-1and 1.87 mg Pt L-1, respectively. In a second study, the 72-hour EC50 for growth rate and biomass were determined to be 0.96 mg Pt L-1and 0.52 mg Pt L-1, respectively. The NOEC was determined to be 0.386 mg Pt L-1.
Key value for chemical safety assessment
Additional information
For hexachloroplatinic acid, data are read across from another platinum(IV) substance that also contains a chloro ligand, platinum(IV) chloride.
The acute toxicity of platinum (as platinum (IV) chloride) to the duckweed Lemna minor was assessed in the publication by Bednarova et al. (2014). The study is reliable with acceptable restrictions. It was not conducted according to GLP and has some limitations in design or reporting, but otherwise it is adequate for assessment. The standard test guideline OECD 221 was followed. A static test of 7 days was carried out to investigate antioxidant and enzymatic activities, alongside a microbiotest to analyse the effects of the test item to the morphology and the vegetative growth of plant colonies. Six nominal concentrations of the test item were tested. The 168-hour EC50 of platinum(IV) chloride for growth inhibition to Lemna minor was determined to be 12.16 μmol test item L-1 (7.04 μmol Pt L-1), corresponding to 4.096 mg test item L-1 (2.372 mg Pt L-1).
The toxicity of platinum (as platinum (IV) chloride) to the duckweed Lemna minor was assessed in the publication by Bednarova et al. (2012). The study is reliable with acceptable restrictions. It was not conducted according to GLP, but the standard test guideline OECD 221 was followed. A static test of 7 days was carried out to investigate the effects of the test item to the vegetative growth of exposed duckweeds. Five nominal concentrations of the test item were tested. The 7-d EC50 of platinum(IV) chloride for biomass (area under the growth curve) and growth inhibition to Lemna minor were determined to be 13.63 μM (7.89 μM Pt) and 19.55 μM (11.32 μM Pt), respectively, which corresponded to 4.59 mg test item L-1 (2.66 mg Pt L-1) and 6.59 mg test item L-1 (3.81 mg Pt L-1), respectively.
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