Registration Dossier
Registration Dossier
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EC number: 230-811-7 | CAS number: 7328-17-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Justification for type of information:
- The positive findings in vitro where Ethoxy ethoxy ethyl acrylate (CAS No. 7328-17-8) demonstrated marked toxicity and induced statistically significant increases in the frequency of cells with chromosome aberrations, in both the absence and presence of a liver enzyme metabolizing system (S9) and thus was considered to be clastogenic to human lymphocytes in vitro, needs to be further evaluated in vivo. In accordance to ECHA guidance R7A (version 6.0, 2017); in case of negative OECD 471 and positive OECD 473, no OECD 476 (HPRT) is needed, and a testing proposal should be proposed (appropriate in vivo study). Thus an in vivo chromosome aberration test (OECD 474) is proposed.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- Testing proposal based on positive findings in vitro (OECD 473)
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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