Registration Dossier
Registration Dossier
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EC number: 230-811-7 | CAS number: 7328-17-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- EC Number:
- 230-811-7
- EC Name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- Cas Number:
- 7328-17-8
- Molecular formula:
- C9H16O4
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethyl acrylate
- Test material form:
- liquid
- Details on test material:
- Name of the test substance used in the study report: Aethyldiglykolacrylat
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 223 g, females 167 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- 0.5% aqueous CMC preparation and 2 - 3 drops Cremophor EL
Form of administration: emulsion
Concentrations used: 5.62, 6.81, 8.25, 10, 12.1, 14.7 and 17.8% (w/v) - Doses:
- 562, 681, 825, 1000, 1210, 1470 and 1780 µl/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 106 mg/kg bw
- Remarks on result:
- other: original value: LD50 ca. 1100 µl/kg
- Mortality:
- 562 and 681 µl/kg: no deaths; 825 µl/kg: 1/10 after 14 days; 1000 µl/kg: 3/10 after 14 days; 1210 µl/kg: 9/10 after 14 days; 1470 µl/kg: 9/10 after 14 days; 1780 µl/kg: 10/10 after 14 days
- Clinical signs:
- other: Dyspnea, apathy, partly abdominal position, staggering, atony, biting spasms, cyanosis, partly reddish feces and reddish-crusted noses (Ames blood test positive), poor general state
- Gross pathology:
- Heart: acute dilatation; acute congestive hyperemia; glandular stomach: mucosa diffus reddened; proventriculus: border thickening, purulent, fibrinous plaque; slight diverticula formation; adherences with diaphragm; indifferent margins of the liver
Any other information on results incl. tables
Mortality:
Dose (µl/kg) |
Conc. (%) |
Number of animals |
Died within |
||||
1 h |
24 h |
48 h |
7 d |
14 d |
|||
1780 |
17.8 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
1470 |
14.7 |
5 male |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
1210 |
12.1 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 female |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
||
1000 |
10.0 |
5 male |
0/5 |
3/5 |
3/5 |
3/5 |
3/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
825 |
8.25 |
5 male |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
681 |
6.81 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
562 |
5.62 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 was ca. 1106 mg/kg bw.
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