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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
Environment and Quality of Life - Reports (Seventh Series)
Author:
European Commission (EC) - Scientific Committee on Cosmetology (SCC)
Year:
1988
Bibliographic source:
Environment and Quality of Life - Reports (Seventh Series), European Commission (EC) - Scientific Committee on Cosmetology (SCC),1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The skin irritation study of chemical Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate (CAS No: 6359-82-6) was conducted on rabbits to assess the degree of irritation caused by the chemical.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate
EC Number:
228-808-0
EC Name:
Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate
Cas Number:
6359-82-6
Molecular formula:
C16H14N4O4S.Na
IUPAC Name:
Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzene sulphonate
Test material form:
solid
Details on test material:
-Name: Acid yellow 11
- Molecular formula: C16H13N4NaO4S
-Molecular weight: 380.359 g/mol
-Substance type: organic
- InChI: 1S/C16H14N4O4S.Na/c1-11-15(18-17-12-5-3-2-4-6-12)16(21)20(19-11)13-7-9-14(10-8-13)25(22,23)24;/h2-10,15H,1H3,(H,22,23,24);/q;+1/p-1/b18-17+;
-Smiles: N1(c2ccc(S(=O)(=O)[O-])cc2)C([C@@H](\N=N\c2ccccc2)C(=N1)C)=O.[Na+]
- Substance Type: Organic
- Physical State: Solid
Specific details on test material used for the study:
-Name: Acid yellow 11
- Molecular formula: C16H13N4NaO4S
-Molecular weight: 380.359 g/mol
-Substance type: organic
- InChI: 1S/C16H14N4O4S.Na/c1-11-15(18-17-12-5-3-2-4-6-12)16(21)20(19-11)13-7-9-14(10-8-13)25(22,23)24;/h2-10,15H,1H3,(H,22,23,24);/q;+1/p-1/b18-17+;
-Smiles: N1(c2ccc(S(=O)(=O)[O-])cc2)C([C@@H](\N=N\c2ccccc2)C(=N1)C)=O.[Na+]

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded skin
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100% (100mg)
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No skin irritating effects were observed in treated rabbits.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate (CAS No: 6359-82-6) was considered to be not irritating to the skin of rabbits.
Executive summary:

Skin irritation study of chemicalSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6) was conducted on intact and abraded skin of rabbits to assess the degree of skin irritation caused by the chemical.

 

When rabbits were exposed with 100 mg of undilutedSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6), no skin irritating effects were observed.

 

Thus the chemicalSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6) was considered to be not irritating to the rabbits’skin.