Registration Dossier
Registration Dossier
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EC number: 262-075-8 | CAS number: 60142-95-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 1-(aminomethyl)cyclohexaneacetic acid hydrochloride
- EC Number:
- 262-075-8
- EC Name:
- 1-(aminomethyl)cyclohexaneacetic acid hydrochloride
- Cas Number:
- 60142-95-2
- Molecular formula:
- C9H17NO2.ClH
- IUPAC Name:
- 2-[1-(aminomethyl)cyclohexyl]acetic acid hydrochloride
- Details on test material:
- Name of test material (as cited in study report): Gabapentin HCl
- Molecular formula (if other than submission substance): C9H17NO2.HCl
- Molecular weight (if other than submission substance): 207.7 g/mol
- Substance type: organic
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- -1.33
- pH:
- 4
- Remarks on result:
- other: Temperature range from 20.6°C to 22.0°C
- Type:
- log Pow
- Partition coefficient:
- -1.17
- pH:
- 7
- Remarks on result:
- other: Temperature range from 20.6°C to 22.0°C
- Type:
- log Pow
- Partition coefficient:
- -1.18
- pH:
- 9
- Remarks on result:
- other: Temperature range from 20.6°C to 22.0°C
Applicant's summary and conclusion
- Conclusions:
- The log Pow of the test item was determined to be:
log Pow = - 1.33 at pH 4
log Pow = - 1.17 at pH 7
log Pow = - 1.18 at pH 9
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