Registration Dossier
Registration Dossier
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EC number: 436-100-1 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 420 EC Directive 92/69/EEC Annex V Test B1 bis OPPTS 870.1100
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: Sprague-Dawley rats
Administration / exposure
- Vehicle:
- other: SNEA administered as supplied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 mg/kg bw
- Mortality:
- Male: 50 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 50 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 500 mg/kg bw; Number of animals: 1; Number of deaths: 1
- Clinical signs:
- Signs of toxicity related to dose levels:In the dose ranging study, there was one death at 500 mg/kgdose level. Prior to death, major clinical signs includedconvulsions, laboured breathing, prostration and theappearance of a white substance at the mouth. Theanimal was found dead within 25 min of dosing.As a result of the mortality and clinical observations, thedefinitive test was conducted at 50 mg/kg. No prematuredecendants resulted at this dose level and there were noadverse clinical signs noted during the study.
- Gross pathology:
- Effects on organs:Necropsy was only conducted on animals in the definitivetest. No abnormalities were noted.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
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