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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics
Author:
Wilma F. Bergfeld, Donald V.Belsito, Curtis D. Klaassen, RonaldHill, Daniel Liebler, James G.Marks, Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen
Year:
2011
Bibliographic source:
International Journal of Toxicology; Vol 30, Issue 6_suppl, pp. 270S - 283S; 2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
An eye irritation study was performed to assess the ocular irritation potential of Sodium cumenesulphonate (CAS No: 28348-53-0) in rabbits according to OECD 405 Guidelines.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium cumenesulphonate
EC Number:
248-983-7
EC Name:
Sodium cumenesulphonate
Cas Number:
28348-53-0
Molecular formula:
C9H12O3S.Na
IUPAC Name:
sodium 2-phenylpropane-2-sulfonate
Test material form:
solid
Details on test material:
Name of the test chemical: Sodium cumenesulphonate
Molecular Weight: 223.2468 g/mol
Molecular Formula:C9H12O3S.Na
Substance Type: Organic
SMILES Notation :c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical: Sodium cumenesulphonate
Molecular Weight: 223.2468 g/mol
Molecular Formula:C9H12O3S.Na
Substance Type: Organic
SMILES Notation :c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
Physical State: Solid
Purity: 96%
Impurities:04%

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation were observed in treated rabbits.

Any other information on results incl. tables

Table: Results of eye irritation studies

Chemical name

CAS

Exposure details

Method

Irritation endpoints

Sodium cumenesulphonate

28348-53-0

Not specified

OECD 405

No signs of irritation were observed in rabbits eyes

 

 

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Sodium cumenesulphonate was not irritating to rabbit eyes
Executive summary:

An ocular irritation study in rabbits was performed to assess the irritation potential of Sodium cumenesulphonate.The test was performed in accordance with OECD 405 Guidelines.

Undiluted Sodium cumenesulphonate instilled in to the rabbit eyes and effects were observed (dose and duration not specified)

Sodium cumenesulphonate was not irritating to rabbit eyes.