Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-235-1 | CAS number: 7790-98-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Justification for read-across: a full read-across additional report concerning extrapolation from sodium perchlorate to ammonium perchlorate for genotoxicity endpoint is attached in IUCLID section 13 (CEHTRA 2015).
Ammonium perchlorate was negative in a bacterial gene mutation assay, conducted at the maximal recommended concentration, with and without metabolic activation.
Ammonium perchlorate was negative in a total of three in vivo micronucleus assays, two of which are summarized:
- at up to 1000 mg/kg/day by oral gavage x three days in mice (key study: lethality at 2000 mg/kg once): Sharma 1998
- at up to 500 mg/kg/day by i.p. injection x three days in mice (supportive study: no report; personal communication between Errol Zeiger and EPA; lethality at 1000 mg/kg twice)
- at up to 10 mg/kg/day in drinking water x 90 days in rats (supportive: non-standard, dose too low): Siglin 1998
The read-across analogue substance sodium perchlorate was negative in an in vitro Mouse Lymphoma Assay with and without metabolic activation, up to 5000 µg/mL.
Justification for selection of genetic toxicity endpoint
Several in vitro/in vivo studies were used to complete this endpoint therefore no specific study could be selected.
Short description of key information:
Ammonium perchlorate was negative in a bacterial gene mutation assay, conducted at the maximal recommended concentration.
Ammonium perchlorate was negative in a total of three in vivo micronucleus assays.
The read-across analogue substance sodium perchlorate was negative in an in vitro Mouse Lymphoma Assay with and without metabolic activation, up to 5000 µg/mL.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the existence of a negative Ames test, three negative independent in vivo micronucleus assays (including two with maximized top-dose based on lethality) and a negative in vitro Mouse Lymphoma Assay on the read-across analogue substance sodium perchlorate, it was considered that ammonium perchlorate is clearly non-genotoxic (neither mutagenic nor clastogenic).
Considering these data, classification of ammonium perchlorate as mutagenic can be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
