Registration Dossier
Registration Dossier
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EC number: 248-890-1 | CAS number: 28188-41-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-Benzenedicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- 1,3-Benzenedicarbonitrile
- Details on test material:
- - Name of test material (IUPAC name): 1,3-Benzenedicarbonitrile
- Common name: 1,3-Dicyanobenzene
- Molecular formula: C8H4N2
- Molecular weight: 128.134 g/mol
- Smiles notation: c1c(cccc1C#N)C#N
- InChl: 1S/C8H4N2/c9-5-7-2-1-3-8(4-7)6-10/h1-4H
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):1,3-Dicyanobenzene
- Molecular formula :C8H4N2
- Molecular weight :128.134 g/mol
- Substance type:organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed at dose 2000 mg/kg bw
- Mortality:
- No mortality was observed at dose 2000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) by dermal application.
- Executive summary:
In acute dermal toxicity study,rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) in the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile(626-17-5)by dermal application.
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