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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other:
Remarks:
This study was classified as reliable with restrictions because the test procedure was in acc ordance with national standard methods with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: US DoT guideline no. 49 CFR 173.240
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
2-methylpropane-2-thiol (CAS # 75-66-1)
IUPAC Name:
2-methylpropane-2-thiol (CAS # 75-66-1)
Details on test material:
Source: Pennwalt Corporation
Batch: 803-TBM-76
Purity: no data

Test animals

Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
72 hours
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritant effects of any kind were discernible at any of the treated skin sites.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a skin irritation and corrosion study, 2-methylpropane-2-thiol was found to be not irritating.
Executive summary:

In a skin irritiation and corrosion study (49 CFR 173.240), six albino rabbits (sex and strain unspecified) received 0.5mL of undiluted 2 -methylpropane-2-thiol (CAS # 75 -66 -1) applied to the intact skin site under standard gauze patches. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. No signs of

irritation were discernible at any of the six treated skin sites. The substance was classified as not irritating based on EC Regulation No 1272.

This study received a Klimisch score of 2 and was classified as reliable with restrictions because the test procedure was in accordance with national standard methods with acceptable restrictions.