Registration Dossier
Registration Dossier
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EC number: 207-529-8 | CAS number: 479-27-6
Endpoint summary
Administrative data
Description of key information
Valid studies for acute oral, dermal and inhalation toxicity are available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 591 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail and are sufficient for evaluation.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 877 mg/m³ air
- Quality of whole database:
- The materials/methods and results are described in detail and are sufficient for evaluation.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail and are sufficient for evaluation.
Additional information
Five male and five female Wistar rats received a single dose of 200, 356, 632, 1124, or 2000 mg/kg bw (male rats) and 200, 356, 474, 632, or 2000 mg/kg bw (female rats) of 1,8-naphtylendiamine per gavage. For male rats a LD50 in the range between 1124 and 2000 mg/kg bw was found, and for female rats a LD50 of 591 mg/kg bw was determined.
Four groups of 5 male and 5 female Wistar rats were nose/head-only exposed to an aerosol concentration of 1,8-naphthylendiamine at an analytical concentration of 0, 156, 413 or 877 mg/m³ (highest technical feasible concentration) for 4 hours. An exposition up to 877 mg/m³ 1,8-naphtylenediamine (highest technical feasible concentration) was tolerated without mortality.
Five male and five female Wistar rats were treated occlusively with a single application of 2000 mg/kg bw of 1,8-naphthylendiamine.
No death occured (LD50 > 2000 mg/kg bw).
Justification for selection of acute toxicity – oral endpoint
key study used
Justification for selection of acute toxicity – inhalation endpoint
key study used
Justification for selection of acute toxicity – dermal endpoint
key study used
Justification for classification or non-classification
Due to the results of the acute oral toxicity study (LD50 = 591 mg/kg bw for female rats) a classification as Xn, R22 (GHS: Acute tox. 4, H302) is justified.
For acute dermal and inhalation toxicity a classification is not justifed based on reliable experimental studies.
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