Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-926-7 | CAS number: 1067-25-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- other: Background Review Document
- Remarks:
- HET-CAM, Review Document
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trimethoxypropylsilane
- EC Number:
- 213-926-7
- EC Name:
- Trimethoxypropylsilane
- Cas Number:
- 1067-25-0
- Molecular formula:
- C6H16O3Si
- IUPAC Name:
- trimethoxy(propyl)silane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- chicken
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- 10% and 100%
- Number of animals or in vitro replicates:
- 2 from at least 2 different laboratories
- Details on study design:
- Ring analysis: Individual laboratory results on tested sibstances were provided in response to a request by NICEATM. In the evaluation, substances were evaluated at 10% and 100% concentration in at least two diferent tesating laboratories. Therefore, evaluation of the reliability of the test method was conducted for each concentration tested.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- in vitro irritation score
- Remarks:
- 10% concentration
- Run / experiment:
- at least 2
- Value:
- > 3.66 - < 3.94
- Vehicle controls validity:
- other: not reported
- Negative controls validity:
- other: not reported
- Positive controls validity:
- other: not reported
- Remarks on result:
- positive indication of irritation
- Remarks:
- slight irritant
- Irritation parameter:
- in vitro irritation score
- Remarks:
- 100% Concentration
- Run / experiment:
- at least 2
- Value:
- > 2.69 - < 15.71
- Vehicle controls validity:
- other: not reported
- Negative controls validity:
- other: not reported
- Positive controls validity:
- other: not reported
- Remarks on result:
- positive indication of irritation
- Remarks:
- severe irritant
- Other effects / acceptance of results:
- Ring analysis: High acceptance of results
Applicant's summary and conclusion
- Interpretation of results:
- other: Irreversible effects on the eye, based on the conditions of this study
- Conclusions:
- The test substance is irritant to eyes.
- Executive summary:
Irritant to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
