Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-977-6 | CAS number: 130-15-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- repeated painting of guinea pig skin
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1,4-Naphthoquinone - BUA Report 211 (October 1998)
- Author:
- GDCh-Advisory Committee on Existing Chemicals (BUA)
- Year:
- 1 998
- Bibliographic source:
- S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- repeated painting of guinea pig skin
- Principles of method if other than guideline:
- No methods have been provided in the literature
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- No methods have been provided in the literature
Test material
- Reference substance name:
- 1,4-naphthoquinone
- EC Number:
- 204-977-6
- EC Name:
- 1,4-naphthoquinone
- Cas Number:
- 130-15-4
- Molecular formula:
- C10H6O2
- IUPAC Name:
- 1,4-naphthoquinone
1
In vivo test system
Test animals
- Species:
- guinea pig
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
The repeated painting of guinea pig skin over an 11-day period with 0.1, 0.5 and 1 % solutions of 1,4 -naphthoquinone in ether on days 1 to 2,3 to 4 and 6 to 11, respectively, caused reddening of the skin at the beginning of the treatment with subsequent brown-blaek scab formation. After the local effects had healed up (by day 21). a 0.1 % solution (which had been shown to cause only minimal irritation after a single application) was applied on day 23 to part of the skin that had not previously been treated; this led to local allergic reactions of the skin (reddening, oedema and nodule formation) in all of the animals, which diminished after 24 hours with mild peeling.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Based on this study, 1,4 -naphthoquinone was considered to be a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
