1,4-naphthoquinone

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation, other

Remarks:

repeated painting of guinea pig skin

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

no guideline followed

Version / remarks:

repeated painting of guinea pig skin

Principles of method if other than guideline:

No methods have been provided in the literature

GLP compliance:

not specified

Type of study:

not specified

Justification for non-LLNA method:

No methods have been provided in the literature

Species:

guinea pig

Remarks on result:

positive indication of skin sensitisation

The repeated painting of guinea pig skin over an 11-day period with 0.1, 0.5 and 1 % solutions of 1,4 -naphthoquinone in ether on days 1 to 2,3 to 4 and 6 to 11, respectively, caused reddening of the skin at the beginning of the treatment with subsequent brown-blaek scab formation. After the local effects had healed up (by day 21). a 0.1 % solution (which had been shown to cause only minimal irritation after a single application) was applied on day 23 to part of the skin that had not previously been treated; this led to local allergic reactions of the skin (reddening, oedema and nodule formation) in all of the animals, which diminished after 24 hours with mild peeling.

Interpretation of results:

Category 1 (skin sensitising) based on GHS criteria

Conclusions:

Based on this study, 1,4 -naphthoquinone was considered to be a skin sensitiser.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)