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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
Method: other acute oral toxicity study
GLP compliance:
no
Test type:
other: acute oral toxicity study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc di(benzothiazol-2-yl) disulphide
EC Number:
205-840-3
EC Name:
Zinc di(benzothiazol-2-yl) disulphide
Cas Number:
155-04-4
Molecular formula:
C7H5NS2.1/2Zn
IUPAC Name:
zinc 1,3-benzothiazole-2-thiolate
Details on test material:
Bantex

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
5000, 6310, 7940, 10000 mg/kg
No. of animals per sex per dose:
5 combined males and females
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
7 500 mg/kg bw
Based on:
test mat.
95% CL:
6 820 - 8 250
Remarks on result:
other: clinical signs and death

Any other information on results incl. tables

Mortality

5000 mg/kg: male (0/3), female (0/2), combinded (0/5)

6310 mg/kg: male (1/2), female (0/3), combinded (1/5)

7940 mg/kg: male (1/3), female (2/2), combinded (3/5)

10000 mg/kg: male (2/2), female (3/3), combinded (5/5)

Time of mortality: One to two days after test substance application

Clinical signs:

Reduced appetite and activity (one to three days in survivors), increasing weakness, collapse, and death

Gross autopsy

Decedents: hemorrhagic areas of the lungs, liver hyperemia, and gastrointestinal inflammation

Survivors (14 day): viscera appeared normal

Applicant's summary and conclusion