1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

Data from peer reviewed handbook. No information provided on the method.

GLP compliance:

not specified

Type of method:

other: not specified.

Key result

Water solubility:

ca. 0.5 g/L

Remarks on result:

other: at room temperature, pH not specified.

Conclusions:

Based on peer reviewed handbook data, the test item has a solubility of ca. 0.5 g/L in water at room temperature.

Executive summary:

'Ullmann's Encyclopedia of Industrial Chemistry' reports the test item to have a solubility of ca. 0.5 g/L in water at room temperature.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2000.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

tested at up to 120 min equilibration time.

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Furfural Español, SA.

Key result

Water solubility:

0.4 g/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: pH not specified.

Water solubility:

650 g/L

Conc. based on:

test mat.

Temp.:

80 °C

Remarks on result:

other: pH not specified.

Conclusions:

The solubility of the test item in water at 20ºC was found to be 0.4 g/L.

Executive summary:

The determination of the water solubility of the test item, using the shake flask method, was carried out by a method similar to OECD 105 (EU A.6, flask method). Successive additions of test item to 100 mL of solvent were performed, and the absorbance of these solutions was measured with a spectrophotometer at 660 nm at different temperatures and times. The final point was considered to be when the absorbance dropped under 0.010 UA. Under test conditions, the solubility of the test item at 20 ºC in water was determined to be 0.4 g/L.

Description of key information

Weight of evidence. Based on the available data, the solubility of the test item at 20ºC was determined to be 0.4 g/L (worst case).

Key value for chemical safety assessment

Water solubility:

0.4 g/L

at the temperature of:

20 °C

Additional information

Weight of evidence: The determination of the water solubility of the test item, using the shake flask method, was carried out by a method similar to OECD 105. Successive additions of test item to 100 mL of solvent were performed, and the absorbance of these solutions was measured with a spectrophotometer at 660 nm at different temperatures and times. The final point was considered to be when the absorbance dropped under 0.010 UA. Under test conditions, the solubility of the test item at 20 ºC in water was determined to be 0.4 g/L. Furthermore, 'Ullmann's Encyclopedia of Industrial Chemistry' (peer reviewed handbook data) reports the test item to have a solubility of ca. 0.5 g/L in water at room temperature.