2,3,3,4,4-pentafluoro-5-methoxy-2,5-bis[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]tetrahydrofuran

Henry's Law constant

Administrative data

Endpoint:

Henry's law constant

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-02-01 to 2013-02-09

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The Henry's Law constant of test substance was determined by the ratio of gas-phase concentration over aqueous phase concentration for a given test system vessel at equilibrium conditions and at ambient temperature and pressure.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,3,3,4,4-pentafluoro-2,5-bis(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-5-methoxyoxolane

EC Number:

812-244-2

Cas Number:

957209-18-6

Molecular formula:

C11H3F19O2

IUPAC Name:

2,3,3,4,4-pentafluoro-2,5-bis(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-5-methoxyoxolane

Specific details on test material used for the study:

- Name of substance as used in the study: L-21343
- Source and lot/batch No.of test material: 161255-76
- Purity: 99.87% sum of (2) isomers
- Expiration date of the lot/batch:9/24/2014

Results and discussion

Henry's Law constant H

Key result

H:

40 400 dimensionless

Temp.:

23.4 °C

Any other information on results incl. tables

Table 1: Summary of Henry’s Law Constant (HLC) forNOVEC 7700

Ratio (Headspace: Aqueous)	Replicate	Time point 1 (Three days)	Time point 2 (Four days)	Time point 3^(1) (Five days)	Time point 4 (Six days)
70 %	1	21400	25100	3170	51600
	2	38300	12200	7090	27000
	Average	29900	18700	5130	39300
	%RPD	57	69	76	63
50 %	1	27800	47300	4170	51200
	2	27400	36800	520	60900
	Average	27600	42100	2350	56100
	%RPD	1.4	25	160	17
30 %	1	55000	46300	22900	37300
	2	48400	47900	12500	65200
	Average	51700	47100	17700	51250
	%RPD	13	3.4	59	54
Intra-Time Point Average % RSD		36400   36	35900   41	8390^(1)   98^(1)	48900   29
Overall Average %RSD (1)		40400 36

 

(1)  Time point 3 sample results were determined to be statistic outliners and are not included for overall average and precision.

Applicant's summary and conclusion

Conclusions:

Under the conditions of this study (average temperature of 23.4°C), overall average HLC (unitless) for NOVEC 7700 was 40400 (%RSD = 36), the overall average log HLC was 4.6 (% RSD = 4.1).

Executive summary:

The Henry's Law constant of NOVEC 7700 was determined by the ratio of gas-phase concentration over aqueous-phase concentration. Duplicate test vessels were filled with water and dosed with NOVEC 7700 gas at three (70%, 50% and 30%) headspace:water ratios. The vials were incubated for 3, 4, 5 and 6 days at ambient temperature of 23.4 °C. Both the headspace and the water phase for each vial were sampled and analyzed in duplicates using gas chromatography/mass spectrometry (GC/MS). The average measured gas phase and waterphase concentrations were used to calculate Henry's Law constant for NOVEC7700 for each test vessel. The samples from time point 3 (5 incubation days) weredetermined to be statistic outliners and are excluded.Under the conditions of this study (average temperature of 23.4°C), overall average HLC (unitless) for NOVEC 7700 was 40400 (%RSD = 36), the overall average log HLC was 4.6 (% RSD = 4.1). The HLC (unitless) of 40400 can be converted to a HLC of 982 atm.m^3/mol.

This study was conducted under GLP compliance with accepted method. It is considered reliable without restrictions.