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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
Version / remarks:
Adopted 28 July 2015
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-bis(methylthio)propan-1-ol
EC Number:
813-843-1
Cas Number:
54884-93-4
Molecular formula:
C5H12OS2
IUPAC Name:
1,3-bis(methylthio)propan-1-ol
Test material form:
liquid
Details on test material:
- Analytical purity: 93 %
- Lot/batch No.: AK16-008

In vitro test system

Test system:
human skin model
Source species:
human
Vehicle:
unchanged (no vehicle)
Control samples:
yes, concurrent negative control
yes, concurrent positive control
yes, concurrent MTT non-specific colour control
Amount/concentration applied:
10 µL
Duration of treatment / exposure:
15 min.
Duration of post-treatment incubation (if applicable):
42 h
Number of replicates:
12

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
% tissue viability
Value:
7.6
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Under the conditions of the study, the test item demonstrated the ability to cause a positive response. However this study does not allow the conclusion on whether the test item is EU CLP/UN GHS Category 1 or Category 2.