BMS 233110-01

Toxicity to microorganisms

Administrative data

Endpoint:

activated sludge respiration inhibition testing

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14th July 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

429-080-9

EC Name:

-

Cas Number:

198904-85-7

Molecular formula:

C17 H21 N3 O2

IUPAC Name:

Tert-butyl 2-[4-(2-pyridinyl) phenylmethyl] hydrazine carboxylate

Test material form:

solid: bulk

Specific details on test material used for the study:

Identity of test material same as for substance defined in section 1

Study design

Total exposure duration:

3 h

Test conditions

Reference substance (positive control):

yes

Remarks:

Dichlorophenol

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 1 000 mg/L

Effect concentrations 2

Key result

Duration:

3 h

Dose descriptor:

NOEC

Effect conc.:

> 100 mg/L

Applicant's summary and conclusion

Conclusions:

The EC50 of BMS233110-01 exceeded 1,000mg/L, the highest dose tested