Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-327-9 | CAS number: 105-75-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List IV
- Author:
- Smyth HF
- Year:
- 1 951
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine vol 4, pp 119-122
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Dibutyl fumarate
- EC Number:
- 203-327-9
- EC Name:
- Dibutyl fumarate
- Cas Number:
- 105-75-9
- Molecular formula:
- C12H20O4
- IUPAC Name:
- dibutyl but-2-enedioate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 8 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Details on study design:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- other: air saturated with the vapour of the test substance, exposure for 8 hours
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: see above
- Mortality:
- no data
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Saturated vapours of the test substance was survived for 8 hours by 100 % of the rats exposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
