Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Toxicity Summary


Acute oral toxicity:

The acute oral toxicity (LD50) is 8530 mg per kg body weight in rats.

Acute dermal toxicity:

The acute dermal toxicity (LD50) is 15.9 mL per kg body weight in rabbits.

Acute toxicity, inhalation:

Rats exposed for 8 hours to saturated vapours of the test substance survived. No mortalities occurred. Therefore the acute toxicity via inhalation is considered to be very low.

Repeated dose toxicity:

NOAEL (rat, oral, 90 d) = 50 mg/kg bw/day (adverse effects kidney)

Reproductive toxicity

NOAEL (rat, developmental toxicity) > 750 mg/kg bw/day (highest dose tested, no developmental toxicity reported)

NOAEL (rat, maternal toxicity) = 250 mg/kg bw/day (body weight and food intake)

Genetic toxicity

The test item gave negative results in one bacterial gene mutation test, one in vitro cytogenetic study and one in vitro gene mutation study, regardless whether tested without or with the addition of metabolizing enzymes.

Toxicokinetic summary

Absorption / distribution

No indication for absorption in the gastrointestinal tract are derived from the results of the acute oral toxicity study. Although the log Pow is relatively high (4.62) and the water solubility is low (11.09 mg/L) uptake via the skin is considered to be low (LD50,dermal,rabbit 15.9 mL/kg bw).


No relevant differences occurred in the three mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test item was obtained from these studies. DBF is expected to be metabolized rapidly in the human body and there is no expectation of desintegration into toxic cleavage products.


No information is available on excretion of the test item.