Registration Dossier
Registration Dossier
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EC number: 807-586-4 | CAS number: 634602-80-5
Endpoint summary
Administrative data
Description of key information
1 DPRA assay, 1 Keratinosense assay
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
An assessment for Skin sensitising potential for the main constituents of this substance was made using DEREK and OASIS Times. For OASIS Times, none of th emain constituents were within domain and so no prediction could be maded. DEREK identified no alerts for sensitising potential.
A Keratinosense assay was performed to assess the potential to activate keratinocytes in vitro. This assay was positive, indicating a this substance may be a skin sensitiser.
The DPRA assay was subsequently performed to assess protein reactivty. This assay was negative indicating that the parent compounds (i.e. not metabolites) do not appear to be able to react with protiens. However it is possible that metabolism could be converting one or more of the main constituents of this material into a more reactive compound. Metabolic activation was not incorporated into this assay.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
WoE indicates substance is not a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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