Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

As Tallow dipropylene triamine is corrosive to skin, no study for skin sensitisation needs to be performed. There are no structural concerns for sensitisation, and cross-reading to data from structurally related substances also do not show a concern. Due to use in industrial and professional setting only, with the application of adequate Personal Protection Measures related to the severe corrosive properties of the diamines, exposures are limited. There are no reports on incidents of sensitisation to triamines available.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

There is no sensitisation data available for C16-18, C18-unsaturated-alkyl dipropylene triamine (Tallow dipropylenetriamine).

As indicated in REACH Annex VII, an in vivo skin sensitisation study does not need to be conducted as the substance is classified as corrosive to the skin.Available data indicate thatTallow dipropylenetriamineis highly corrosive.There are no consumer exposures, only industrial/professional use under circumstances involving the use of PPM following the classification as corrosive cat. 1B. Consequently, due to limited exposures, animal testing is not required.


Additionally, the molecular structure of the Tallow dipropylenetriamine does not contain toxicophores indicating a concern for sensitization. Primary fatty amines are recognised as not sensitising. Available QSARs indicate possible sensitising properties based on structural similarities with ethylene amines known to have sensitising properties, and some other structural similar substances that actuallydohave protein binding properties, and as such are not considered to be predictive for the polyamines.


The profiling of alkyl-diamines (QSAR Toolbox v.3.0) indicates that no alerts are found for protein binding, thiol reactivity is not expected, and that the structure is not represented among the categories of high, moderate or low reactivity in DPRA (direct peptide reactivity assays) for either cysteine or lysine depletion. Additionally, the molecular structure of the triamines does not contain toxicophores indicating a concern for sensitization, and also read across to data available on structurally related branched triamine (Dodecyl dipropylene triamine) and primary amines in general do not indicate a concern.

There are noreports on incidences of sensitisation from industrial production and use of the substance.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

Likelihood of exposures via inhalation is low considering that Tallow dipropylenetriamine is a paste with a high boiling point (> 300 °C) and very low vapour pressure(4.7 x 10-5 Pa at 20°C for the Coco dipropylenetriamine, with the shortest average alkyl chain length representing the highest vapour pressure for the group of polyamines).Its use is limited to industrial and professional users and does not involve the forming of aerosols, particles or droplets of an inhalable size. So exposure to humans via the inhalation route will be unlikely to occur.Additionally, information from profiling for expected protein interaction and QSARs for sensitisation result to a low concern.

Justification for classification or non-classification

Based on limited exposures by dermal route (substance is very corrosive) or by inhalation (very low vapour pressure) and results from a structurally related triamine showing no sensitisation, as well as lack of toxicophores in the structure of polyamines indicating a concern for sensitisation, there are no concerns for sensitisation expected.

However, as a firm conclusion from a study with this compound is lacking, no definite conclusion might be drawn for classification purposes.