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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

There are no repeated dose toxicity data on trichloro(vinyl)silane or its hydrolysis product, vinylsilanetriol, so good quality data for the related substance trimethoxyvinylsilane have been used to assess the general systemic toxicity of trichloro(vinyl)silane. 
In an oral OECD 422 study (Hashima Labs, 2005) in rats, trimethoxyvinylsilane was administered by gavage at doses up to 1000 mg/kg bw/day, for approximately 28 days. The LOAEL was 62.5 mg/kg bw/day (based on decreased relative thymus weight in females and histopathological changes in the urinary bladder of males), and therefore the NOAEL was <62.5 mg/kg bw/day for both sexes.
In a 14-week whole-body inhalation study (BRRC, 1990) in which rats were exposed to concentration of trimethoxyvinylsilane up to 400 ppm, a concentration of 100 ppm was a LOAEC (effects included decreased urine osmolality and sodium, potassium and chloride concentrations in males and slight decrease in body weight and body weight gain in females), and 10 ppm (58 mg/m3) was a NOAEC.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
62.5 mg/kg bw/day
Study duration:

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
58 mg/m³
Study duration:

Additional information

There are no repeated dose toxicity data on tricloro(vinyl)silane or its hydrolysis product, vinylsilanetriol, so good quality data for the related substance trimethoxy(vinyl)silane has been used to assess the general systemic toxicity of trichloro(vinyl)silane. Local effects from the other hydrolysis product, hydrogen chloride (HCl) are not addressed by these data.

Trichloro(vinyl)silane hydrolyses rapidly in contact with water (half-life ca. <1 minute at pH 7), generating HCl and (vinyl)silanetriol. Trimethoxy(vinyl)silane (CAS 2768 -02 -7) hydrolyses more slowly at pH 7 (half-life ca. 0.2 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and vinylsilanetriol. Both parent materials therefore produce a common silanol hydrolysis product. Data obtained via the oral route for trimethoxyvinylsilane are therefore considered appropriate for read-across to trichloro(vinyl)silane.


For the inhalation route, the hydrolysis rate of trimethoxyvinylsilane in the respiratory tract and lungs is unknown, but is likely to be slower than that of trichloro(vinyl)silane. For trichloro(vinyl)silane, the species absorbed following inhalation exposure are mainly hydrolysis products, whereas for trimethoxy(vinyl)silane, absorption of the parent substance may be more significant. Trimethoxy(vinyl)silane has a higher log Kow value (1.08) therefore the proportion of inhaled material which is systemically absorbed is likely to be greater than for trichloro(vinyl)silane. Nevertheless, in the absence of other data, the inhalatory NOAEL for trimethoxy(vinyl)silane is considered to represent a reasonable worst-case for read-across to trichloro(vinyl)silane.

It is of note that the oral NOAEL in rats for methanol is greater (500 mg/kg bw/day) than the dose that is expected to be generated from hydrolysis of trimethoxy(vinyl)silane in the stomach. Therefore the effects of trimethoxy(vinyl)silane following a dose of 62.5 mg/kg bw/day are not thought to be attributable to methanol. Similarly, following inhalation of methanol the NOAEC is an order of magnitide greater than the NOAEC for trimethoxy(vinyl)silane, and it therefore unlikely that systemic effects observed following inhalation of trimethoxy(vinyl)silane are due to methanol.

Repeated dose toxicity: via oral route - systemic effects (target organ) urogenital: urinary bladder

Justification for classification or non-classification

Based on the observed effects on the urinary bladder of males at all dose levels following oral exposure and most levels following inhalation exposure, it is appropriate to classify trimethoxyvinylsilane as STOT RE 2 (bladder), according to the criteria of Regulation 1272/2008. However, at the dose levels tested, corrosive effects of trichloro(vinyl)silane would outweigh any potential systemic effects. It is therefore not considered appropriate to classify trichloro(vinyl)silane for repeated dose toxicity.